長庚大學 藥劑學研究室 Pharmaceutics Laboratory, Chang Gung University

Nirmal, G.R., Liao, C.C., Lin, Z.C., Alshetaili, A., Hwang, E., Yang, S.C., Fang, J.Y. (2023) Topically applied pH-responsive nanogels for alkyl radical-based therapy against psoriasiform hyperplasia. Drug. Deliv., 30, 2245169.

Tsai, M.J., Lin, C.Y., Trousil, J., Sung, C.T., Lee, M.H., Fang, J.Y., Yang, S.C. (2023) Proteinase K/retinoic acid-loaded cationic liposomes as multifunctional anti-acne therapy to disorganize biofilm and regulate keratinocyte proliferation. Int. J. Nanomed., 18, 3879‒3896.

Chang, Y.T., Huang, T.H., Alalaiwe, A., Hwang, E., Fang, J.Y. (2023) Small interfering RNA-based nanotherapeutics for treating skin-related diseases. Expert Opin. Drug Deliv., 20, 757‒772.

Yang, S.C., Lin, C.F., Alshetaili, A., Aljuffalin, I.A., Chien, M.Y., Fang, J.Y.* (2023) Dual antibacterial and regenerative activities of platelet-rich plasma combined with β-lactam antibiotics are effective to treat MRSA-infected skin wound: the cell- and animal-based studies. Biomed. Pharmacother., 165, 115017.

Huang, T.H., Chen, C.J., Lin, H.C.A., Chen, C.H., Fang, J.Y. (2023) Self-nanoemulsifying drug delivery system-containing the poorly absorbed drug‒valsartan in post-bariatric surgery. Int. J. Nanomed., 18, 2647‒2658.

Nirmal, G.R., Lin, Z.C., Lin, C.H., Sung, C.T., Liao, C.C., Fang, J.Y. (2022) Polydopamine/IR820 nanoparticles as topical phototheranostics for inhibiting psoriasiform lesions through dual photothermal and photodynamic treatments. Biomater. Sci., 10, 6172–6189.

Wang, P.W., Lin, T.Y., Yang, P.M., Fang, J.Y., Li, W.T., Pan, T.L. (2022) Therapeutic efficacy of Scutellaria baicalensis Georgi against psoriasis-like lesions via regulating the responses of keratinocyte and macrophage. Biomed. Pharmacother., 155, 113798.

Lee, W.R., Huang, T.H., Hu, S., Alalaiwe, A., Wang, P.W., Lo, P.C., Fang, J.Y., Yang, S.C. (2022) Laser-assisted nanoparticle delivery to promote skin absorption and penetration depth of retinoic acid with the aim for treating photoaging. Int. J. Pharm., 627, 122162.

Lee, W.R., Chou, W.L., Lin, Z.C., Sung, C.T., Lin, C.Y., Fang, J.Y. (2022) Laser-assisted nanocarrier delivery to achieve cutaneous siRNA targeting for attenuating psoriasiform dermatitis. J. Control. Release, 347, 590–606.

Tseng, C.H., Lin, C.F., Aljuffali, I.A., Huang, J.R., Yang, S.H., Fang, J.Y. (2022) The effectiveness of synthetic methoxylated isoflavones in delivering to the skin and alleviating psoriasiform lesions via topical absorption. Int. J. Pharm., 617, 121629.

Yamazoe, E., Fang, J.Y., Tahara, K. (2021) Oral mucus-penetrating PEGylated liposomes to improve drug absorption: Differences in the interaction mechanisms of a mucoadhesive liposome. Int. J. Pharm., 593, 120148.

Lee, W.R., Hsiao, C.Y., Huang, T.H., Sung, C.T., Wang, P.W., Cheng, W.T., Fang, J.Y. (2021) Low-fluence laser-facilitated platelet-rich plasma permeation for treating MRSA-infected wound and photoaging of the skin. Int. J. Pharm., 595, 120242.

Liao, C.C., Yu, H.P., Yang, S.C., Alalaiwe, A., Dai, Y.S., Liu, F.C., Fang, J.Y. (2021) Multifunctional lipid-based nanocarriers with antibacterial and anti-inflammatory activities for treating MRSA bacteremia in mice. J. Nanobiotechnol., 19, 48.

Lin, Z.C., Hwang, T.L., Huang, T.H., Tahara, K., Trousil, J., Fang, J.Y. (2021) Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation. Theranostics, 11, 4567-4584.

Lin, Y.C., Fang, Y.P., Hung, C.F., Yu, H.P., Alalaiwe, A., Wu, Z.Y., Fang, J.Y. (2021) Multifunctional TiO₂/SBA-15 mesoporous silica hybrids loaded with organic sunscreens for skin application: the role in photoprotection and pollutant adsorption with reduced sunscreen permeation. Colloids Surf. B, 202, 111658.

Lee, W.R., Lin, Y.K., Alalaiwe, A., Wang, P.W., Liu, P.Y., Fang, J.Y. (2020) Fractional laser-mediated siRNA delivery for mitigating psoriasis-like lesions via IL-6 silencing. Mol. Ther.-Nucl. Acids, 19, 240-251.

Yu, H.P., Liu, F.C., Umoro, A., Lin, Z.C., Elzoghby, A.O., Hwang, T.L., Fang, J.Y. (2020) Oleic acid-based nanosystems for mitigating acute respiratory distress syndrome in mice through neutrophil suppression: how the particulate size affects therapeutic efficiency. J. Nanobiotechnol., 18, 25.

Kamel, N.M, Helmy, M.W., Abdelfattah, E.Z., Khattab, S.N., Ragab, D., Samaha, M.W., Fang, J.Y., Elzoghby, A.O. (2020) Inhalable dual-targeted hybrid lipid nanocore-protein shell composites for combined delivery of genistein and all-trans retinoic acid to lung cancer cells. ACS Biomater. Sci. Eng., 6, 71-87.

Trousil, J., Pavliš, O., Kubíčková, P., Škorič, M., Marešová, V., Pavlova, E., Knudsen, K.D., Dai, Y.S., Zimmerman, M., Dartois, V., Fang, J.Y., Hrubý, M. (2020) Antitubercular nanocarrier monotherapy: study of in vivo efficacy and pharmacokinetics for rifampicin. J. Control. Release, 321, 312-323.

Wu, C.Y.J., Chen, C.H., Lin, C.Y., Feng, L.Y., Lin, Y.C., Wei, K.C., Huang, C.Y., Fang, J.Y., Chen, P.Y. (2020) CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase-2. Neuro-Oncology, 22, 253-266.

Chou, W.L., Lee, T.H., Huang, T.H., Wang, P.W., Chen, Y.P., Chen, C.C., Chang, Z.Y., Fang, J.Y., Yang, S.C. (2019) Coenzyme Q₀ from Antrodia cinnamomea exhibits drug-resistant bacteria eradication and keratinocyte inflammation mitigation to ameliorate infected atopic dermatitis in mouse. Front. Pharmacol., 10, 1445.

Chen, P.Y., Wu, C.Y.J., Fang, J.H., Chen, H.C., Feng, L.Y., Huang, C.Y., Wei, K.C., Fang, J.Y., Lin, C.Y. (2019) Functionl change of effector tumor-infiltrating CCR5+CD38+HLA-DR+CD8+ T cells in glioma microenvironment. Front. Immunol., 10, 2395.

Fang, J.Y., Lin, Y.K., Wang, P.W., Alalaiwe, A., Yang, Y.C., Yang, S.C. (2019) The droplet-size effect of squalene@cetylpyridinium chloride nanoemulsions on antimicrobial potency against planktonic and biofilm MRSA. Int. J. Nanomed., 14, 8133-8147.

Weng, J.R., Huang, T.H., Lin, Z.C., Alalaiwe, A., Fang, J.Y.* (2019) Cutaneous delivery of [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, mitigates psoriasiform lesion by blocking MAPK/NF-κB/AP-1 activation. Biomed. Pharmacother., 119, 109398.

Hsiao, C.Y., Yang, S.C., Alalaiwe, A., Fang, J.Y. (2019) Laser ablation and topical drug delivery: a review of recent advances. Expert Opin. Drug Deliv., 16, 937-952.

Abdelaziz, H.M., Gaber, M., Abd-Elwakil, M.M., Mabrouk, M.T., Elgohary, M.M., Kamel, N.M., Kabary, D.M., Freag, M.S., Samaha, M.W., Mortada, S.M., Elkhodairy, K.A., Fang, J.Y., Elzoghby, A.O. (2018) Inhalable particulate drug delivery systems for lung cancer therapy: Nanoparticles, microparticles, nanocomposites and nanoaggregates. J. Control. Release, 269, 374-392.

Fang, J.Y., Huang, T.H., Hung, C.F., Huang, Y.L., Aljuffali, I.A., Liao, W.C., Lin, C.F. (2018) Derivatization of honokiol by integrated acetylation and methylation for improved cutaneous delivery and anti-inflammatory potency. Eur. J. Pharm. Sci., 114, 189-198.

Hsu, C.Y., Sung, C.T., Aljuffali, I.A., Chen, C.H., Hu, K.Y., Fang, J.Y. (2018) Intravenous anti-MRSA phosphatiosomes mediate enhanced affinity to pulmonary surfactants for effective treatment of infectious pneumonia. Nanomed.-Nanotechnol. Biol. Med., 14, 215-225.

Chuang, S.Y., Lin, C.H., Huang, T.H., Fang, J.Y. (2018) Lipid-based nanoparticles as a potential delivery approach in the treatment of rheumatoid arthritis. Nanomaterials, 8, 42.

Lin, M.H., Lin, C.F., Yang, S.C., Hung, C.F., Fang, J.Y. (2018) The interplay between nanoparticles and neutrophils. J. Biomed. Nanotechnol., 14, 66-85.

Fang, J.Y., Lin, Y.K., Wang, S.W., Yu, Y.C., Lee, R.S. (2017) Acid and light dual- stimuli-cleavable polymeric micelles. J. Polym. Res., 24, 3.

Lin, M.H., Hung, C.F., Aljuffali, I.A., Sung, C.T., Huang, C.T., Fang, J.Y. (2017) Cationic amphiphile in phospholipid bilayer or oil-water interface of nanocarriers affects planktonic and biofilm bacteria killing. Nanomed.-Nanotechnol. Biol. Med., 13, 353-361.

Hsu, C.Y., Chen, C.H., Aljuffali, I.A., Dai, Y.S., Fang, J.Y. (2017) Nanovesicle delivery to the liver via RBP and PDGF receptors: how the targeting ligands affect biodistribution. Nanomedicine, 12, 317-331.

Heieh, P.W., Hung, C.F., Lin, C.H., Huang, C.W., Fang, J.Y. (2017) Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation. Eur. J. Pharm. Biopharm., 114, 154-163.

Yu, H.P., Aljuffali, I.A., Fang, J.Y. (2017) Injectable drug-loaded nanocarriers for lung cancer treatments. Curr. Pharm. Design, 23, 481-494.

• Fang, J.Y., Wang, P.W., Huang, C.H., Chen, M.H., Wu, Y.R., Pan, T.L. (2016) Skin aging caused by intrinsic or extrinsic processes characterized with functional proteomics. Proteomics, 16, 2718-2731.


• Chen, Y.L., Hwang, T.L., Yu, H.P., Fang, J.Y., Chong, K.Y., Chang, Y.W., Chen, C.Y., Yang, H.W., Chang, W.Y., Hsieh, P.W. (2016) Ilex kaushue and its bioactive component 3,5-dicaffeoylquinic acid protected mice from lipopolysaccharide-induced acute lung injury. Sci. Rep., 6, 34243.


• Yu, I.C., Tsai, Y.F., Fang, J.T., Yeh, M.M., Fang, J.Y., Liu, C.Y. (2016) Effects of mouthwash interventions on xerostomia and unstimulated whole saliva flow rate among hemodialysis patients: A randomized controlled study. Int. J. Nurs. Stud., 63, 9-17.


• Aljuffali, I.A., Lin, C.F., Chen, C.H., Fang, J.Y.* (2016) The codrug approach for facilitating drug delivery and bioactivity. Expert Opin. Drug Deliv., 13, 1311-1325.


• Aljuffali, I.A., Fang, C.L., Chen, C.H., Fang, J.Y.* (2016) Nanomedicine as a strategy for natural compound delivery to prevent and treat cancers. Curr. Pharm. Design, 22, 4219-4231.

• Fang, J.Y., Lin, Y.K., Wang, S.W., Li, Y.C., Lee, R.S. (2015) Synthesis and characterization of dual-stimuli-responsive micelles based on poly(N-isopropylacrylamide) and polycarbonate with photocleavable moieties. React. Funct. Polym., 95, 46-54.


• Yang, S.C., Hung, C.F., Aljuffali, I.A., Fang, J.Y.* (2015) The roles of the virulence factor IpaB in Shigella spp. in the escape from immune cells and invasion of epithelial cells. Microbiol. Res., 181, 43-51.


• Aljuffali, I.A., Huang, C.H., Fang, J.Y.* (2015) Nanomedical strategies for targeting skin microbiomes. Curr. Drug Metab., 16, 255-271.


• Fang, J.Y., Wang, S.W., Li, Y.C., Lee, R.S. (2015) Bio-recognizable and photo-cleavable block copolymers based on sugar and poly(4-substituted-ε-caprolactone) bearing a photo-cleavable junction. J. Polym. Res., 22, 155.


• Fang, C.L., Wen, C.J., Aljuffali, I.A., Sung, C.T., Huang, C.L., Fang, J.Y.* (2015) Passive targeting of phosphatiosomes increases rolipram delivery to the lungs for treatment of acute lung injury: an animal study. J. Control. Release, 213, 69-78.

• Fang, J.Y., Wang, P.W., Huang, C.H., Hung, Y.Y., Pan, T.L. (2014) Evaluation of the hepatotoxic risk caused by lead acetate via skin exposure using a proteome approach. Proteomics, 14, 2588-2599.


• Lin, C.F., Wen, C.J., Aljuffali, I.A., Huang, C.L., Fang, J.Y.* (2014) Quantiosomes as a multimodal nanocarrier for integrating bioimaging and anticancer drug delivery. Pharm. Res., 31, 2664-2676.


• Hsieh, P.W., Aljuffali, I.A., Fang, C.L., Chang, S.H., Fang, J.Y.* (2014) Hydroquinone-salicylic acid conjugates as novel anti-melasma actives show superior skin targeting compared to the parent drugs. J. Dermatol. Sci., 76, 120-131.


• Hung, C.F., Chen, W.Y., Aljuffali, I.A., Shih, H.C., Fang, J.Y.* (2014) The risk of hydroquinone and sunscreen over-absorption via photodamaged skin is not greater in senescent skin as compared to young skin: nude mouse as an animal model. Int. J. Pharm., 471, 135-145.


• Yang, S.C., Lin, C.H., Sung, C.T., Fang, J.Y.* (2014) Antibacterial activities of bacteriocins: application in foods and pharmaceuticals. Front. Microbiol., 5, article 241.

• Chiang, Y.R., Li, A., Leu, Y.L., Fang, J.Y., Lin, Y.K. (2013) An in vitro study of the antimicrobial effects of indigo naturalis prepared from Strobilanthes formosanus Moore. Molecules, 18, 14381-14396.


• Hsieh, P.W., Chen, W.Y., Aljuffali, I.A., Chen, C.C., Fang, J.Y.* (2013) Co-drug strategy for promoting skin targeting and minimizing transdermal diffusion of hydroquinone and tranexamic acid. Curr. Med. Chem., 20, 4080-4092.


• Chen, W.Y., Fang, C.L., Al-Suwayeh, S.A., Yang, H.H., Li, Y.C., Fang, J.Y.* (2013) Risk assessment of excess drug and sunscreen absorption via skin with ablative fractional laser resurfacing: optimization of the applied dose for postoperative care. Lasers Med. Sci., 28, 1363-1374.


• Hsu, S.H., Wen, C.J., Al-Suwayeh, S.A., Huang, Y.J., Fang, J.Y.* (2013) Formulation design and evaluation of quantum dot-loaded nanostructured lipid carriers for integrating bioimaging and anticancer therapy. Nanomedicine, 8, 1253-1269.


• Wen, C.J., Sung, C.T., Aljuffali, I.A., Huang, Y.J., Fang, J.Y.* (2013) Nanocomposite liposomes containing quantum dots and anticancer drugs for bioimaging and therapeutic delivery: a comparison of cationic, PEGylated, and deformable liposomes. Nanotechnology, 24, 325101.

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G.R. Nirmal