長庚大學藥劑學研究室 Pharmaceutics Laboratory, Chang Gung University

10月 03 週二 202311:39
2023

Nirmal, G.R., Liao, C.C., Lin, Z.C., Alshetaili, A., Hwang, E., Yang, S.C., Fang, J.Y. (2023) Topically applied pH-responsive nanogels for alkyl radical-based therapy against psoriasiform hyperplasia. Drug. Deliv., 30, 2245169.
Tsai, M.J., Lin, C.Y., Trousil, J., Sung, C.T., Lee, M.H., Fang, J.Y., Yang, S.C. (2023) Proteinase K/retinoic acid-loaded cationic liposomes as multifunctional anti-acne therapy to disorganize biofilm and regulate keratinocyte proliferation. Int. J. Nanomed., 18, 3879‒3896.

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10月 03 週二 202311:28
2022

Nirmal, G.R., Lin, Z.C., Lin, C.H., Sung, C.T., Liao, C.C., Fang, J.Y. (2022) Polydopamine/IR820 nanoparticles as topical phototheranostics for inhibiting psoriasiform lesions through dual photothermal and photodynamic treatments. Biomater. Sci., 10, 6172–6189.
Wang, P.W., Lin, T.Y., Yang, P.M., Fang, J.Y., Li, W.T., Pan, T.L. (2022) Therapeutic efficacy of Scutellaria baicalensis Georgi against psoriasis-like lesions via regulating the responses of keratinocyte and macrophage. Biomed. Pharmacother., 155, 113798.

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8月 13 週五 202109:00
2021

Yamazoe, E., Fang, J.Y., Tahara, K. (2021) Oral mucus-penetrating PEGylated liposomes to improve drug absorption: Differences in the interaction mechanisms of a mucoadhesive liposome. Int. J. Pharm., 593, 120148.

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3月 09 週二 202117:19
2020

Lee, W.R., Lin, Y.K., Alalaiwe, A., Wang, P.W., Liu, P.Y., Fang, J.Y. (2020) Fractional laser-mediated siRNA delivery for mitigating psoriasis-like lesions via IL-6 silencing. Mol. Ther.-Nucl. Acids, 19, 240-251.

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12月 31 週二 201909:02
2019

Chou, W.L., Lee, T.H., Huang, T.H., Wang, P.W., Chen, Y.P., Chen, C.C., Chang, Z.Y., Fang, J.Y., Yang, S.C. (2019) Coenzyme Q₀ from Antrodia cinnamomea exhibits drug-resistant bacteria eradication and keratinocyte inflammation mitigation to ameliorate infected atopic dermatitis in mouse. Front. Pharmacol., 10, 1445.

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11月 24 週四 201614:21
2018

Abdelaziz, H.M., Gaber, M., Abd-Elwakil, M.M., Mabrouk, M.T., Elgohary, M.M., Kamel, N.M., Kabary, D.M., Freag, M.S., Samaha, M.W., Mortada, S.M., Elkhodairy, K.A., Fang, J.Y., Elzoghby, A.O. (2018) Inhalable particulate drug delivery systems for lung cancer therapy: Nanoparticles, microparticles, nanocomposites and nanoaggregates. J. Control. Release, 269, 374-392.

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個人分類：近年研究成果 Publications in the recent years

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6月 13 週二 201709:54
2017

Fang, J.Y., Lin, Y.K., Wang, S.W., Yu, Y.C., Lee, R.S. (2017) Acid and light dual- stimuli-cleavable polymeric micelles. J. Polym. Res., 24, 3.

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11月 24 週四 201614:32
2016

Fang, J.Y., Wang, P.W., Huang, C.H., Chen, M.H., Wu, Y.R., Pan, T.L. (2016) Skin aging caused by intrinsic or extrinsic processes characterized with functional proteomics. Proteomics, 16, 2718-2731.

Chen, Y.L., Hwang, T.L., Yu, H.P., Fang, J.Y., Chong, K.Y., Chang, Y.W., Chen, C.Y., Yang, H.W., Chang, W.Y., Hsieh, P.W. (2016) Ilex kaushue and its bioactive component 3,5-dicaffeoylquinic acid protected mice from lipopolysaccharide-induced acute lung injury. Sci. Rep., 6, 34243.

Yu, I.C., Tsai, Y.F., Fang, J.T., Yeh, M.M., Fang, J.Y., Liu, C.Y. (2016) Effects of mouthwash interventions on xerostomia and unstimulated whole saliva flow rate among hemodialysis patients: A randomized controlled study. Int. J. Nurs. Stud., 63, 9-17.

Aljuffali, I.A., Lin, C.F., Chen, C.H., Fang, J.Y.* (2016) The codrug approach for facilitating drug delivery and bioactivity. Expert Opin. Drug Deliv., 13, 1311-1325.

Aljuffali, I.A., Fang, C.L., Chen, C.H., Fang, J.Y.* (2016) Nanomedicine as a strategy for natural compound delivery to prevent and treat cancers. Curr. Pharm. Design, 22, 4219-4231.

Lin, Z.C., Lee, C.W., Tsai, M.H., Ko, H.H., Fang, J.Y., Chiang, Y.C., Liang, C.J., Hsu, L.F., Hu, S.C.S., Yen, F.L. (2016) Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress. Int. J. Nanomed., 11, 3907-3926.

Lin, C.F., Hung, C.F., Aljuffali, I.A., Huang, Y.L., Liao, W.C., Fang, J.Y.* (2016) Methylation and esterification of magnolol for ameliorating cutaneous targeting and therapeutic index by topical application. Pharm. Res., 33, 2152-2167.

Lee, W.R., Shen, S.C., Aljuffali, I.A., Lin, Y.K., Huang, C.W., Fang, J.Y.* (2016) Non-ablative fractional laser assists cutaneous delivery of small- and macro-molecules with minimal bacterial infection risk. Eur. J. Pharm. Sci., 92, 1-10.

Lee, C.W., Lin, Z.C., Hu, S.C.S., Chiang, Y.C., Hsu, L.F., Lin, Y.C., Lee, I.T., Tsai, M.H., Fang, J.Y.* (2016) Urban particulate matter down-regulates filaggrin via COX2 expression/PGE2 production leading to skin barrier dysfunction. Sci. Rep., 6, 27995.

Liu, K.S., Chen, Y.W., Aljuffali, I.A., Chang, C.W., Wang, J.J., Fang, J.Y.* (2016) Topically applied mesoridazine exhibits the strongest cutaneous analgesia and minimized skin disruption among tricyclic antidepressants: the skin absorption assessment. Eur. J. Pharm. Biopharm., 105, 59-68.

Lee, C.W., Lin, Z.C., Hsu, L.F., Fang, J.Y., Chiang, Y.C., Tsai, M.H., Lee, M.H., Li, S.Y., Hu, S.C., Lee, I.T., Yen, F.L. (2016) Eupafolin ameliorate COX-2 expression and PGE₂ production in particulate pollutants-exposed human keratinocytes through ROS/MAPKs pathways. J. Ethnopharmacol., 189, 300-309.

Lin, C.H., Chang, S.H., Fang, J.Y.* (2016) Recent advances using phosphodiesterase 4 (PDE4) inhibitors to treat inflammatory disorders: animal and clinical studies. Curr. Drug Ther., 11, 21-40.

Yang, S.C., Aljuffali, I.A., Sung, C.T., Lin, C.F., Fang, J.Y.* (2016) Antimicrobial activity of topically-applied soyaethyl morpholinium ethosulfate micelles against Staphylococcus species. Nanomedicine, 11, 657-671.

Pan, T.L., Wang, P.W., Hung, C.F., Aljuffali, I.A., Dai, Y.S., Fang, J.Y.* (2016) The impact of retinol loading and surface charge on the hepatic delivery of lipid nanoparticles. Colloids Surf. B, 141, 584-594.

Aljuffali, I.A., Lin, Y.K., Fang, J.Y.* (2016) Noninvasive approach for enhancing small interfering RNA delivery percutaneously. Expert Opin. Drug Deliv., 13, 265-280.

Chuang, S.Y., Lin, C.F., Aljuffali, I.A., Fang, J.Y.* (2016) Specific targeting of engineered nanoparticles to activated macrophages. Curr. Nanosci., 12, 63-69.

Fang, Y.P., Yang, S.H., Lee, C.H., Aljuffali, I.A., Kao, H.C., Fang, J.Y.* (2016) What is the discrepancy between drug permeation into/across intact and diseased skins? Atopic dermatitis as a model. Int. J. Pharm., 497, 277-286.

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11月 24 週四 201614:31
2015

Fang, J.Y., Lin, Y.K., Wang, S.W., Li, Y.C., Lee, R.S. (2015) Synthesis and characterization of dual-stimuli-responsive micelles based on poly(N-isopropylacrylamide) and polycarbonate with photocleavable moieties. React. Funct. Polym., 95, 46-54.

Yang, S.C., Hung, C.F., Aljuffali, I.A., Fang, J.Y.* (2015) The roles of the virulence factor IpaB in Shigella spp. in the escape from immune cells and invasion of epithelial cells. Microbiol. Res., 181, 43-51.

Aljuffali, I.A., Huang, C.H., Fang, J.Y.* (2015) Nanomedical strategies for targeting skin microbiomes. Curr. Drug Metab., 16, 255-271.

Fang, J.Y., Wang, S.W., Li, Y.C., Lee, R.S. (2015) Bio-recognizable and photo-cleavable block copolymers based on sugar and poly(4-substituted-ε-caprolactone) bearing a photo-cleavable junction. J. Polym. Res., 22, 155.

Fang, C.L., Wen, C.J., Aljuffali, I.A., Sung, C.T., Huang, C.L., Fang, J.Y.* (2015) Passive targeting of phosphatiosomes increases rolipram delivery to the lungs for treatment of acute lung injury: an animal study. J. Control. Release, 213, 69-78.

Hung, C.F., Chen, W.Y., Hsu, C.Y., Aljuffali, I.A., Shih, H.C., Fang, J.Y.* (2015) Cutaneous penetration of soft nanoparticles via photodamaged skin: lipid-based and polymer-based nanocarriers for drug delivery. Eur. J. Pharm. Biopharm., 94, 94-105.

Aljuffali, I.A., Pan, T.L., Sung, C.T., Chang, S.H., Fang, J.Y.* (2015) Anti-PDGF receptor β antibody-conjugated squarticles loaded with minoxidil for alopecia treatment by targeting hair follicles and dermal papilla cells. Nanomed.-Nanotechnol. Biol. Med., 11, 1321-1330.

Lee, R.S., Lin, C.H., Aljuffali, I.A., Hu, K.Y., Fang, J.Y.* (2015) Passive targeting of thermosensitive diblock copolymer micelles to the lungs: synthesis and characterization of poly(N-isopropylacrylamide)-block-poly(ε-caprolactone). J. Nanobiotechnol., 13, 42.

Aljuffali, I.A., Hsu, C.Y., Lin, Y.K., Fang, J.Y.* (2015) Cutaneous delivery of natural antioxidants: the enhancement approaches. Curr. Pharm. Design, 21, 2745-2757.

Lee, W.R., Shen, S.C., Sun, C.K., Aljuffali, I.A., Suen, S.Y., Lin, Y.K., Wang, J.J., Fang, J.Y.* (2015) Fractional thermolysis by bipolar radiofrequency facilitates cutaneous delivery of peptide and siRNA with minor loss of barrier function. Pharm. Res., 32, 1704-1713.

Pan, T.L., Wang, P.W., Aljuffali, I.A., Huang, C.T., Lee, C.W., Fang, J.Y.* (2015) The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption. J. Dermatol. Sci., 78, 51-60.

Chen, C.H., Chang, C.C., Shih, T.H., Aljuffali, I.A., Yeh, T.S., Fang, J.Y.* (2015) Self-nanoemulsifying drug delivery systems ameliorate the oral delivery of silymarin in rats with Roux-en-Y gastric bypass surgery. Int. J. Nanomed., 10, 2403-2416.

Hwang, T.L., Hsu, C.Y., Aljuffali, I.A., Chen, C.H., Chang, Y.T., Fang, J.Y.* (2015) Cationic liposomes evoke inflammatory responses and neutrophil extracellular traps (NETs) toward human neutrophils. Colloids Surf. B, 128, 119-126.

Hwang, T.L., Aljuffali, I.A., Lin, C.F., Chang, Y.T., Fang, J.Y.* (2015) Cationic additives in nanosystems interact with human neutrophils to activate cytotoxicity and inflammatory response: lipid nanoparticles versus polymeric nanoparticles. Int. J. Nanomed., 10, 371-385.

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11月 24 週四 201614:29
2014

Fang, J.Y., Wang, P.W., Huang, C.H., Hung, Y.Y., Pan, T.L. (2014) Evaluation of the hepatotoxic risk caused by lead acetate via skin exposure using a proteome approach. Proteomics, 14, 2588-2599.

Lin, C.F., Wen, C.J., Aljuffali, I.A., Huang, C.L., Fang, J.Y.* (2014) Quantiosomes as a multimodal nanocarrier for integrating bioimaging and anticancer drug delivery. Pharm. Res., 31, 2664-2676.

Hsieh, P.W., Aljuffali, I.A., Fang, C.L., Chang, S.H., Fang, J.Y.* (2014) Hydroquinone-salicylic acid conjugates as novel anti-melasma actives show superior skin targeting compared to the parent drugs. J. Dermatol. Sci., 76, 120-131.

Hung, C.F., Chen, W.Y., Aljuffali, I.A., Shih, H.C., Fang, J.Y.* (2014) The risk of hydroquinone and sunscreen over-absorption via photodamaged skin is not greater in senescent skin as compared to young skin: nude mouse as an animal model. Int. J. Pharm., 471, 135-145.

Yang, S.C., Lin, C.H., Sung, C.T., Fang, J.Y.* (2014) Antibacterial activities of bacteriocins: application in foods and pharmaceuticals. Front. Microbiol., 5, article 241.

Lee, W.R., Shen, S.C., Chen, W.Y., Aljuffali, I.A., Suen, S.Y., Fang, J.Y.* (2014) Noninvasive delivery of siRNA and plasmid DNA into skin by fractional ablation: erbium:YAG laser versus CO₂ laser. Eur. J. Pharm. Biopharm., 86, 315-323.

Hsieh, P.W., Wen, C.J., Yu, H.P., Aljuffali, I.A., Huang, Y.H., Fang, J.Y.* (2014) Nanostructured lipid carriers containing a high percentage of a Pluronic copolymer increase the biodistribution of novel PDE4 inhibitors for the treatment of traumatic hemorrhage. J. Biomed. Nanotechnol., 10, 1520-1535.

Lin, C.H., Aljuffali, I.A., Fang, J.Y.* (2014) Lasers as an approach for promoting drug delivery via skin. Expert Opin. Drug Deliv., 11, 599-614.

Pan, T.L., Wang, P.W., Aljuffali, I.A., Leu, Y.L., Hung, Y.Y., Fang, J.Y.* (2014) Coumarin derivatives, but not coumarin itself, cause skin irritation via topical delivery. Toxicol. Lett., 226, 173-181.

Lee, W.R., Shen, S.C., Aljuffali, I.A., Li, Y.C., Fang, J.Y.* (2014) Impact of different vehicles for laser-assisted drug permeation via skin: full-surface versus fractional ablation. Pharm. Res., 31, 382-393.

Pan, T.L., Wang, P.W., Aljuffali, I.A., Hung, Y.Y., Lin, C.F., Fang, J.Y.* (2014) Dermal toxicity elicited by phthalates: evaluation of skin absorption, immunohistology, and functional proteomics. Food Chem. Toxicol., 65, 105-114.

Aljuffali, I.A., Sung, C.T., Shen, F.M., Huang, C.T., Fang, J.Y.* (2014) Squarticles as a lipid nanocarrier for delivering diphencyprone and minoxidil to hair follicles and human dermal papilla cells. AAPS J., 16, 140-150.

Hwang, T.L., Sung, C.T., Aljuffali, I.A., Chang, Y.T., Fang, J.Y.* (2014) Cationic surfactants in the form of nanoparticles and micelles elicit different human neutrophil responses: a toxicological study. Colloids Surf. B, 114, 334-341.

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長庚大學藥劑學研究室 Pharmaceutics Laboratory, Chang Gung University

實驗室主持人: 方嘉佑教授 Professor Jia-You Fang

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