長庚大學 藥劑學研究室 Pharmaceutics Laboratory, Chang Gung University

Nirmal, G.R., Liao, C.C., Lin, Z.C., Alshetaili, A., Hwang, E., Yang, S.C., Fang, J.Y. (2023) Topically applied pH-responsive nanogels for alkyl radical-based therapy against psoriasiform hyperplasia. Drug. Deliv., 30, 2245169.

Tsai, M.J., Lin, C.Y., Trousil, J., Sung, C.T., Lee, M.H., Fang, J.Y., Yang, S.C. (2023) Proteinase K/retinoic acid-loaded cationic liposomes as multifunctional anti-acne therapy to disorganize biofilm and regulate keratinocyte proliferation. Int. J. Nanomed., 18, 3879‒3896.

Chang, Y.T., Huang, T.H., Alalaiwe, A., Hwang, E., Fang, J.Y. (2023) Small interfering RNA-based nanotherapeutics for treating skin-related diseases. Expert Opin. Drug Deliv., 20, 757‒772.

Yang, S.C., Lin, C.F., Alshetaili, A., Aljuffalin, I.A., Chien, M.Y., Fang, J.Y.* (2023) Dual antibacterial and regenerative activities of platelet-rich plasma combined with β-lactam antibiotics are effective to treat MRSA-infected skin wound: the cell- and animal-based studies. Biomed. Pharmacother., 165, 115017.

Huang, T.H., Chen, C.J., Lin, H.C.A., Chen, C.H., Fang, J.Y. (2023) Self-nanoemulsifying drug delivery system-containing the poorly absorbed drug‒valsartan in post-bariatric surgery. Int. J. Nanomed., 18, 2647‒2658.

Chang, Z.Y., Chen, C.W., Tsai, M.J., Chen, C.C., Alshetaili, A., Hsiao, Y.T., Fang, J.Y. (2023) The elucidation of structure-activity and structure-permeation relationships for the cutaneous delivery of phytosterols to attenuate psoriasiform inflammation. Int. Immunopharmacol., 119, 110202.

Lin, C.Y., Yu, H.P., Chang, Y.T., Lin, Z.C., Alalaiwe, A., Hwang, T.L., Fang, J.Y. (2023) Targeting anti-inflammatory immunonanocarriers to human and murine neutrophils via Ly6 antigen for psoriasiform dermatitis alleviation. Biomater. Sci., 11, 873–893.

Lin, Z.C., Hsu, C.Y., Hwang, E., Wang, P.W., Fang, J.Y. (2023) The role of cytokines/chemokines in aging skin immune microenvironment. Mech. Ageing Dev., 210, 111761.

Nirmal, G.R., Lin, Z.C., Lin, C.H., Sung, C.T., Liao, C.C., Fang, J.Y. (2022) Polydopamine/IR820 nanoparticles as topical phototheranostics for inhibiting psoriasiform lesions through dual photothermal and photodynamic treatments. Biomater. Sci., 10, 6172–6189.

Wang, P.W., Lin, T.Y., Yang, P.M., Fang, J.Y., Li, W.T., Pan, T.L. (2022) Therapeutic efficacy of Scutellaria baicalensis Georgi against psoriasis-like lesions via regulating the responses of keratinocyte and macrophage. Biomed. Pharmacother., 155, 113798.

Lee, W.R., Huang, T.H., Hu, S., Alalaiwe, A., Wang, P.W., Lo, P.C., Fang, J.Y., Yang, S.C. (2022) Laser-assisted nanoparticle delivery to promote skin absorption and penetration depth of retinoic acid with the aim for treating photoaging. Int. J. Pharm., 627, 122162.

Lee, W.R., Chou, W.L., Lin, Z.C., Sung, C.T., Lin, C.Y., Fang, J.Y. (2022) Laser-assisted nanocarrier delivery to achieve cutaneous siRNA targeting for attenuating psoriasiform dermatitis. J. Control. Release, 347, 590–606.

Tseng, C.H., Lin, C.F., Aljuffali, I.A., Huang, J.R., Yang, S.H., Fang, J.Y. (2022) The effectiveness of synthetic methoxylated isoflavones in delivering to the skin and alleviating psoriasiform lesions via topical absorption. Int. J. Pharm., 617, 121629.

Lee, W.R., Hsiao, C.Y., Chang, Z.Y., Wang, P.W., Aljuffali, I.A., Lin, J.Y., Fang, J.Y.* (2022) Cutaneous delivery of cosmeceutical peptides enhanced by picosecond- and nanosecond-domain Nd:YAG lasers with quick recovery of the skin barrier function: comparison with microsecond-domain ablative lasers. Pharmaceutics, 14, 450.

Trousil, J., Matějková, J., Dai, Y.S., Urbánek, T., Šlouf, M., Škorič, M., Nejedlý, T., Hrubý, M., Fang, J.Y. (2022) Nanocrystalline chloroxine posesses broad-spectrum antimicrobial activities and excellent skin tolerability in mice. Nanomedicine, 17, 137–149.

Fang, J.Y., Huang, T.H., Chen, W.J., Aljuffali, I.A., Hsu, C.Y. (2022) Rhubarb hydroxyanthraquinones act as antiobesity agents to inhibit adipogenesis and enhance lipolysis. Biomed. Pharmacother., 146, 112497.

Lin, C.F., Chuang, S.Y., Huang, T.H., Nguyen, T.M.H., Wang, P.W., Alalaiwe, A., Fang, J.Y. (2022) A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: the evaluation of percutaneous absorption and anti-inflammatory potency. Biomed. Pharmacother., 145, 112482.

Yamazoe, E., Fang, J.Y., Tahara, K. (2021) Oral mucus-penetrating PEGylated liposomes to improve drug absorption: Differences in the interaction mechanisms of a mucoadhesive liposome. Int. J. Pharm., 593, 120148.

Lee, W.R., Hsiao, C.Y., Huang, T.H., Sung, C.T., Wang, P.W., Cheng, W.T., Fang, J.Y. (2021) Low-fluence laser-facilitated platelet-rich plasma permeation for treating MRSA-infected wound and photoaging of the skin. Int. J. Pharm., 595, 120242.

Liao, C.C., Yu, H.P., Yang, S.C., Alalaiwe, A., Dai, Y.S., Liu, F.C., Fang, J.Y. (2021) Multifunctional lipid-based nanocarriers with antibacterial and anti-inflammatory activities for treating MRSA bacteremia in mice. J. Nanobiotechnol., 19, 48.

Lin, Z.C., Hwang, T.L., Huang, T.H., Tahara, K., Trousil, J., Fang, J.Y. (2021) Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation. Theranostics, 11, 4567-4584.

Lin, Y.C., Fang, Y.P., Hung, C.F., Yu, H.P., Alalaiwe, A., Wu, Z.Y., Fang, J.Y. (2021) Multifunctional TiO₂/SBA-15 mesoporous silica hybrids loaded with organic sunscreens for skin application: the role in photoprotection and pollutant adsorption with reduced sunscreen permeation. Colloids Surf. B, 202, 111658.

Lin, M.H., Hung, C.F., Sung, H.C., Yang, S.C., Yu, H.P., Fang, J.Y. (2021) The bioactivities of resveratrol and its naturally occurring derivatives on skin. J. Food Drug Anal., 29, 15-38.

Nirmal, G.R., Lin, Z.C., Tsai, M.J., Yang, S.C., Alalaiwe, A., Fang, J.Y. (2021) Photothermal treatment by PLGA-gold nanorod-isatin nanocomplexes under near-infrared irradiation for alleviating psoriasiform hyperproliferation. J. Control. Release, 333, 487-499.

Chuang, S.Y., Chen, C.Y., Yang, S.C., Alalaiwe, A., Lin, C.H., Fang, J.Y. (2021) 2,4-Dimethoxy-6-methylbenzene-1,3-diol, a benzenoid from Antrodia cinnamomea, mitigates psoriasiform inflammation by suppressing MAPK/NF-κB phosphorylation and GDAP1L1/Drp1 translocation. Front. Immunol., 12, 664425.

Alalaiwe, A., Chen, C.Y., Chang, Z.Y., Sung, J.T., Chuang, S.Y., Fang, J.Y. (2021) Psoriasiform inflammation is associated with mitochondrial fission/GDAP1L1 signaling in macrophages. Int. J. Mol. Sci., 22, 10410.

Anwar, D.M., El-Sayed, M., Reda, A., Fang, J.Y., Khattab, S.N., Elzoghby, A.O. (2021) Recent advances in herbal combination nanomedicine for cancer: delivery technology and therapeutic outcomes. Expert Opin. Drug Deliv., 18, 1609-1625.

Fang, J.Y., Chou, W.L., Lin, C.F., Sung, C.T., Alalaiwe, A., Yang, S.C. (2021) Facile biofilm penetration of cationic liposomes loaded with DNase I/proteinase K to eradicate Cutibacterium acnes biofilm for treating cutaneous and catheter infections. Int. J. Nanomed., 16, 8121-8138.

Lee, W.R., Lin, Y.K., Alalaiwe, A., Wang, P.W., Liu, P.Y., Fang, J.Y. (2020) Fractional laser-mediated siRNA delivery for mitigating psoriasis-like lesions via IL-6 silencing. Mol. Ther.-Nucl. Acids, 19, 240-251.

Yu, H.P., Liu, F.C., Umoro, A., Lin, Z.C., Elzoghby, A.O., Hwang, T.L., Fang, J.Y. (2020) Oleic acid-based nanosystems for mitigating acute respiratory distress syndrome in mice through neutrophil suppression: how the particulate size affects therapeutic efficiency. J. Nanobiotechnol., 18, 25.

Kamel, N.M, Helmy, M.W., Abdelfattah, E.Z., Khattab, S.N., Ragab, D., Samaha, M.W., Fang, J.Y., Elzoghby, A.O. (2020) Inhalable dual-targeted hybrid lipid nanocore-protein shell composites for combined delivery of genistein and all-trans retinoic acid to lung cancer cells. ACS Biomater. Sci. Eng., 6, 71-87.

Trousil, J., Pavliš, O., Kubíčková, P., Škorič, M., Marešová, V., Pavlova, E., Knudsen, K.D., Dai, Y.S., Zimmerman, M., Dartois, V., Fang, J.Y., Hrubý, M. (2020) Antitubercular nanocarrier monotherapy: study of in vivo efficacy and pharmacokinetics for rifampicin. J. Control. Release, 321, 312-323.

Wu, C.Y.J., Chen, C.H., Lin, C.Y., Feng, L.Y., Lin, Y.C., Wei, K.C., Huang, C.Y., Fang, J.Y., Chen, P.Y. (2020) CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase-2. Neuro-Oncology, 22, 253-266.

Alalaiwe, A., Lin, C.F., Hsiao, C.Y., Chen, E.L., Lin, C.Y., Lien, W.C., Fang, J.Y. (2020) Development of flavanone and its derivatives as topical agents against psoriasis: the prediction of therapeutic efficiency through skin permeation evaluation and cell-based assay. Int. J. Pharm., 581, 119256.

Yu, H.P., Liu, F.C., Lin, C.Y., Umoro, A., Trousil, J., Hwang, T.L., Fang, J.Y. (2020) Suppression of neutrophilic inflammation can be modulated by the droplet size of anti-inflammatory nanoemulsions. Nanomedicine, 15, 773-791.

Yeh, Y.C., Huang, T.H., Yang, S.C., Chen, C.C., Fang, J.Y. (2020) Nano-based drug delivery or targeting to eradicate bacteria for infection mitigation: a review of recent advances. Front. Chem., 8, 286.

Alalaiwe, A., Lin, Y.K., Lin, C.H., Wang, P.W., Lin, J.Y., Fang, J.Y. (2020) The absorption of polycyclic aromatic hydrocarbons into the skin to elicit cutaneous inflammation: the establishment of structure–permeation and in silico–in vitro–in vivo relationships. Chemosphere, 255, 126955.

Yu, H.P., Liu, F.C., Umoro, A., Lin, Z.C., Elzoghby, A.O., Hwang, T.L., Fang, J.Y. (2020) Oleic acid-based nanosystems for mitigating acute respiratory distress syndrome in mice through neutrophil suppression: how the particulate size affects therapeutic efficiency. J. Nanobiotechnol., 18, 25.

Cheng, C.Y., Lin, Y.K., Yang, S.C., Alalaiwe, A., Lin, C.J., Fang, J.Y., Lin, C.F. (2020) Percutaneous absorption of resveratrol and its oligomers to relieve psoriasiform lesions: in silico, in vitro and in vivo evaluations. Int. J. Pharm., 585, 119507.

Fang, J.Y., Tang, K.W., Yang, S.H., Alalaiwe, A., Yang, Y.C., Tseng, C.H., Yang, S.C. (2020) Synthetic naphthofuranquinone derivatives are effective in eliminating drug-resistant Candida albicans in hyphal, biofilm, and intracellular forms: an application for skin-infection treatment. Front. Microbiol., 11, 2053.

Tang, K.W., Lin, Z.C., Wang, P.W., Alalaiwe, A., Tseng, C.H., Fang, J.Y.* (2020) Facile skin targeting of a thalidomide analog containing benzyl chloride moiety alleviates experimental psoriasis via the suppression of MAPK/NF-κB/AP-1 phosphorylation in keratinocytes. J. Dermatol. Sci., 99, 90-99.

Chou, W.L., Lee, T.H., Huang, T.H., Wang, P.W., Chen, Y.P., Chen, C.C., Chang, Z.Y., Fang, J.Y., Yang, S.C. (2019) Coenzyme Q₀ from Antrodia cinnamomea exhibits drug-resistant bacteria eradication and keratinocyte inflammation mitigation to ameliorate infected atopic dermatitis in mouse. Front. Pharmacol., 10, 1445.

Chen, P.Y., Wu, C.Y.J., Fang, J.H., Chen, H.C., Feng, L.Y., Huang, C.Y., Wei, K.C., Fang, J.Y., Lin, C.Y. (2019) Functionl change of effector tumor-infiltrating CCR5+CD38+HLA-DR+CD8+ T cells in glioma microenvironment. Front. Immunol., 10, 2395.

Fang, J.Y., Lin, Y.K., Wang, P.W., Alalaiwe, A., Yang, Y.C., Yang, S.C. (2019) The droplet-size effect of squalene@cetylpyridinium chloride nanoemulsions on antimicrobial potency against planktonic and biofilm MRSA. Int. J. Nanomed., 14, 8133-8147.

Weng, J.R., Huang, T.H., Lin, Z.C., Alalaiwe, A., Fang, J.Y.* (2019) Cutaneous delivery of [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, mitigates psoriasiform lesion by blocking MAPK/NF-κB/AP-1 activation. Biomed. Pharmacother., 119, 109398.

Hsiao, C.Y., Yang, S.C., Alalaiwe, A., Fang, J.Y. (2019) Laser ablation and topical drug delivery: a review of recent advances. Expert Opin. Drug Deliv., 16, 937-952.

Yang, S.C., Tang, K.W., Lin, C.H., Alalaiwe, A., Tseng, C.H., Fang, J.Y. (2019) Discovery of furanoquinone derivatives as a novel class of DNA polymerase and gyrase inhibitors for MRSA eradication in cutaneous infection. Front. Microbiol., 10, 1197.

Lin, C.Y., Hsu, C.Y., Elzoghby, A.O., Alalaiwe, A., Hwang, T.L., Fang, J.Y. (2019) Oleic acid as the active agent and lipid matrix in cilomilast-loaded nanocarriers to assist PDE4 inhibition of activated neutrophils for mitigating psoriasis-like lesions. Acta Biomater., 90, 350-361.

Lee, W.R., Hsiao, C.Y., Huang, T.H., Wang, C.L., Alalaiwe, A., Chen, E.L., Fang, J.Y. (2019) Post-irradiation recovery time strongly influences fractional laser-facilitated skin absorption. Int. J. Pharm., 564, 48-58.

Zayed, D.G., Ebrahim, S.M., Helmy, M.W., Khattab, S.N., Bahey-El-Din, M., Fang, J.Y., Elkhodairy, K.A., Elzoghby, A.O. (2019) Combining hydrophilic chemotherapy and hydrophobic phytotherapy via tumor-targeted albumin-QDs nano-hybrids: covalent coupling and phospholipid complexation approaches. J. Nanobiotechnol., 7, 17.

Hsu, C.Y., Wang, P.W., Alalaiwe, A., Lin, Z.C., Fang, J.Y. (2019) Use of lipid nanocarriers to improve oral delivery of vitamins. Nutrients, 11, 68.

Fang, J.Y., Lin, C.H., Huang, T.H., Chuang, S.Y. (2019) In vivo rodent models of type 2 diabetes and their usefulness for evaluating flavonoid bioactivity. Nutrients, 11, 530.

Abdelaziz, H.M., Gaber, M., Abd-Elwakil, M.M., Mabrouk, M.T., Elgohary, M.M., Kamel, N.M., Kabary, D.M., Freag, M.S., Samaha, M.W., Mortada, S.M., Elkhodairy, K.A., Fang, J.Y., Elzoghby, A.O. (2018) Inhalable particulate drug delivery systems for lung cancer therapy: Nanoparticles, microparticles, nanocomposites and nanoaggregates. J. Control. Release, 269, 374-392.

Fang, J.Y., Huang, T.H., Hung, C.F., Huang, Y.L., Aljuffali, I.A., Liao, W.C., Lin, C.F. (2018) Derivatization of honokiol by integrated acetylation and methylation for improved cutaneous delivery and anti-inflammatory potency. Eur. J. Pharm. Sci., 114, 189-198.

Hsu, C.Y., Sung, C.T., Aljuffali, I.A., Chen, C.H., Hu, K.Y., Fang, J.Y. (2018) Intravenous anti-MRSA phosphatiosomes mediate enhanced affinity to pulmonary surfactants for effective treatment of infectious pneumonia. Nanomed.-Nanotechnol. Biol. Med., 14, 215-225.

Chuang, S.Y., Lin, C.H., Huang, T.H., Fang, J.Y. (2018) Lipid-based nanoparticles as a potential delivery approach in the treatment of rheumatoid arthritis. Nanomaterials, 8, 42.

Lin, M.H., Lin, C.F., Yang, S.C., Hung, C.F., Fang, J.Y. (2018) The interplay between nanoparticles and neutrophils. J. Biomed. Nanotechnol., 14, 66-85.

Liu, F.C., Yu, H.P., Lin, C.Y., Elzoghby, A.O., Hwang, T.L., Fang, J.Y. (2018) Use of cilomilast-loaded phosphatiosomes to suppress neutrophilic inflammation for attenuating acute lung injury: the effect of nanovesicular surface charge. J. Nanobiotechnol., 16, 35.

Lee, W.R., Shen, S.C., Sung, C.T., Liu, P.Y., Fang, J.Y. (2018) Is the fractional laser still effective in assisting cutaneous macromolecule delivery in barrier-deficient skin? Psoriasis and atopic dermatitis as the disease models. Pharm. Res., 35, 128.

Chuang, S.Y., Lin, C.H., Sung, C.T., Fang, J.Y. (2018) Murine models of psoriasis and their usefulness for drug discovery. Expert Opin. Drug Discov., 13, 551-562.

Kabary, D.M., Helmy, M.W., Elkhodairy, K.A., Fang, J.Y., Elzoghby, A.O. (2018) Hyaluronate/lactoferrin layer-by-layer-coated lipid nanocarriers for targeted co-delivery of rapamycin and berberine to lung carcinoma. Colloids Surf. B, 169, 183-194.

Kabary, D.M., Helmy, M.W., Abdelfattah, E.Z.A., Fang, J.Y., Elkhodairy, K.A., Elzoghby, A.O. (2018) Inhalable multi-compartmental phospholipid enveloped lipid core nanocomposites for localized mTOR inhibitor/herbal combined therapy of lung carcinoma. Eur. J. Pharm. Biopharm., 130, 152-164.

Alalaiwe, A., Wang, P.W., Lu, P.L., Chen, Y.P., Fang, J.Y., Yang, S.C. (2018) Synergistic anti-MRSA activity of cationic nanostructured lipid carriers in combination with oxacillin for cutaneous application. Front. Microbiol., 9, 1493.

Lin, Y.C., Lin, C.F., Alalaiwe, A., Wang, P.W., Fang, Y.P., Fang, J.Y. (2018) UV filter entrapment in mesoporous silica hydrogel for skin protection against UVA with minimization of percutaneous absorption. Eur. J. Pharm. Sci., 122, 185-194.

Elgohary, M.M., Helmy, M.W., Abdelfattah, E.Z.A., Ragab, D.M., Mortada, S.M., Fang, J.Y., Elzoghby, A.O. (2018) Targeting sialic acid residues on lung cancer cells by inhalable boronic acid-decorated albumin nanocomposites for combined chemo/herbal therapy. J. Control. Release, 285, 230-243.

Huang, T.H., Wang, P.W., Yang, S.C., Chou, W.L., Fang, J.Y. (2018) Cosmetic and therapeutic applications of fish oil’s fatty acids on the skin. Mar. Drugs, 16, 256.

Chen, C.H., Chen, C.J., Elzoghby, A.O., Yeh, T.S., Fang, J.Y. (2018) Self-assembly and directed assembly of lipid nanocarriers for prevention of liver fibrosis in obese rats: a comparison with the therapy of bariatric surgery. Nanomedicine, 13, 1551-1566.

Yang, S.C., Huang, T.H., Chiu, C.H., Chou, W.L., Alalaiwe, A., Yeh, Y.C., Su, K.W., Fang, J.Y. (2018) The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorata. J. Dermatol. Sci., 92, 188-196.

Lin, Z.C., Hsieh, P.W., Hwang, T.L., Chen, C.Y., Sung, C.T., Fang, J.Y. (2018) Topical application of anthranilate derivatives ameliorates psoriatic inflammation in a mouse model by inhibiting keratinocyte-derived chemokine expression and neutrophil infiltration. FASEB J., 32, 6783-6795.

Tang, K.W., Lin, Z.C., Chen, Y.L., Tzeng, C.C., Fang, J.Y., Tseng, C.H. (2018) Synthesis and biological evaluation of thalidomide derivatives as potential anti-psoriasis agents. Int. J. Mol. Sci., 19, 3061.

Fang, J.Y., Lin, Y.K., Wang, S.W., Yu, Y.C., Lee, R.S. (2017) Acid and light dual- stimuli-cleavable polymeric micelles. J. Polym. Res., 24, 3.

Lin, M.H., Hung, C.F., Aljuffali, I.A., Sung, C.T., Huang, C.T., Fang, J.Y. (2017) Cationic amphiphile in phospholipid bilayer or oil-water interface of nanocarriers affects planktonic and biofilm bacteria killing. Nanomed.-Nanotechnol. Biol. Med., 13, 353-361.

Hsu, C.Y., Chen, C.H., Aljuffali, I.A., Dai, Y.S., Fang, J.Y. (2017) Nanovesicle delivery to the liver via RBP and PDGF receptors: how the targeting ligands affect biodistribution. Nanomedicine, 12, 317-331.

Heieh, P.W., Hung, C.F., Lin, C.H., Huang, C.W., Fang, J.Y. (2017) Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation. Eur. J. Pharm. Biopharm., 114, 154-163.

Yu, H.P., Aljuffali, I.A., Fang, J.Y. (2017) Injectable drug-loaded nanocarriers for lung cancer treatments. Curr. Pharm. Design, 23, 481-494.

Wang, T.H., Chan, C.W., Fang, J.Y., Shih, Y.M., Liu, Y.W., Wang, T.C.V., Chen, C.Y. (2017) 2-O-methylmagnolol upregulates the long non-coding RNA, GAS5, and enhances apoptosis in skin cancer cells. Cell Death Dis., 8, e2638.

Liu, K.S., Huang, T.H., Aljuffali, I.A., Chen, E.L., Wang, J.J., Fang, J.Y. (2017) Exploring the structure-permeation relationship of topical tricyclic antidepressants used for skin analgesia. Int. J. Pharm., 523, 386-397.

Gaber, M., Medhat, W., Hany, M., Saher, N., Fang, J.Y., Elzoghby, A. (2017) Protein-lipid nanohybrids as emerging platforms for drug and gene delivery: challenges and outcomes. J. Control. Release, 254, 75-91.

Lin, C.H., Chen, C.H., Lin, Z.C., Fang, J.Y. (2017) Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers. J. Food Drug Anal., 25, 219-234.

Yang, S.C., Tseng, C.H., Wang, P.W., Lu, P.L., Weng, Y.H., Yen, F.L., Fang, J.Y. (2017) Pterostilbene, a methoxylated resveratrol derivative, efficiently eradicates planktonic, biofilm, and intracellular MRSA by topical application. Front. Microbiol., 8, 1103.

Yang, S.C., Yen, F.L., Wang, P.W., Aljuffali, I.A., Weng, Y.H., Tseng, C.H., Fang, J.Y. (2017) Naphtho[1,2-b]furan-4,5-dione is a potent anti-MRSA agent against planktonic, biofilm, and intracellular bacteria. Future Microbiol., 12, 1059-1073.

Chen, C.H., Huang, T.H., Elzoghby, A., Wang, P.W., Chang, C.W., Fang, J.Y. (2017) Squarticles as the nanoantidotes to sequester the overdosed antidepressant for detoxification. Int. J. Nanomed., 12, 8071-8083.

Hsu, C.Y., Yang, S.C., Sung, C.T., Weng, Y.H., Fang, J.Y. (2017) Anti-MRSA malleable liposomes carrying chloramphenicol for ameliorating hair follicle targeting. Int. J. Nanomed., 12, 8227-8238.

Chuang, S.Y., Lin, Y.K., Lin, C.F., Wang, P.W., Chen, E.L., Fang, J.Y. (2017) Elucidating the skin delivery of aglycone and glycoside flavonoids: how the structures affect cutaneous absorption. Nutrients, 9, 1304.

• Fang, J.Y., Wang, P.W., Huang, C.H., Chen, M.H., Wu, Y.R., Pan, T.L. (2016) Skin aging caused by intrinsic or extrinsic processes characterized with functional proteomics. Proteomics, 16, 2718-2731.
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• Chen, Y.L., Hwang, T.L., Yu, H.P., Fang, J.Y., Chong, K.Y., Chang, Y.W., Chen, C.Y., Yang, H.W., Chang, W.Y., Hsieh, P.W. (2016) Ilex kaushue and its bioactive component 3,5-dicaffeoylquinic acid protected mice from lipopolysaccharide-induced acute lung injury. Sci. Rep., 6, 34243.
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• Yu, I.C., Tsai, Y.F., Fang, J.T., Yeh, M.M., Fang, J.Y., Liu, C.Y. (2016) Effects of mouthwash interventions on xerostomia and unstimulated whole saliva flow rate among hemodialysis patients: A randomized controlled study. Int. J. Nurs. Stud., 63, 9-17.
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• Aljuffali, I.A., Lin, C.F., Chen, C.H., Fang, J.Y.* (2016) The codrug approach for facilitating drug delivery and bioactivity. Expert Opin. Drug Deliv., 13, 1311-1325.
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• Aljuffali, I.A., Fang, C.L., Chen, C.H., Fang, J.Y.* (2016) Nanomedicine as a strategy for natural compound delivery to prevent and treat cancers. Curr. Pharm. Design, 22, 4219-4231.
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• Lin, Z.C., Lee, C.W., Tsai, M.H., Ko, H.H., Fang, J.Y., Chiang, Y.C., Liang, C.J., Hsu, L.F., Hu, S.C.S., Yen, F.L. (2016) Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress. Int. J. Nanomed., 11, 3907-3926.
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• Lin, C.F., Hung, C.F., Aljuffali, I.A., Huang, Y.L., Liao, W.C., Fang, J.Y.* (2016) Methylation and esterification of magnolol for ameliorating cutaneous targeting and therapeutic index by topical application. Pharm. Res., 33, 2152-2167.
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• Lee, W.R., Shen, S.C., Aljuffali, I.A., Lin, Y.K., Huang, C.W., Fang, J.Y.* (2016) Non-ablative fractional laser assists cutaneous delivery of small- and macro-molecules with minimal bacterial infection risk. Eur. J. Pharm. Sci., 92, 1-10.
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• Lee, C.W., Lin, Z.C., Hu, S.C.S., Chiang, Y.C., Hsu, L.F., Lin, Y.C., Lee, I.T., Tsai, M.H., Fang, J.Y.* (2016) Urban particulate matter down-regulates filaggrin via COX2 expression/PGE2 production leading to skin barrier dysfunction. Sci. Rep., 6, 27995.
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• Liu, K.S., Chen, Y.W., Aljuffali, I.A., Chang, C.W., Wang, J.J., Fang, J.Y.* (2016) Topically applied mesoridazine exhibits the strongest cutaneous analgesia and minimized skin disruption among tricyclic antidepressants: the skin absorption assessment. Eur. J. Pharm. Biopharm., 105, 59-68.
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• Lee, C.W., Lin, Z.C., Hsu, L.F., Fang, J.Y., Chiang, Y.C., Tsai, M.H., Lee, M.H., Li, S.Y., Hu, S.C., Lee, I.T., Yen, F.L. (2016) Eupafolin ameliorate COX-2 expression and PGE₂ production in particulate pollutants-exposed human keratinocytes through ROS/MAPKs pathways. J. Ethnopharmacol., 189, 300-309.
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• Lin, C.H., Chang, S.H., Fang, J.Y.* (2016) Recent advances using phosphodiesterase 4 (PDE4) inhibitors to treat inflammatory disorders: animal and clinical studies. Curr. Drug Ther., 11, 21-40.
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• Yang, S.C., Aljuffali, I.A., Sung, C.T., Lin, C.F., Fang, J.Y.* (2016) Antimicrobial activity of topically-applied soyaethyl morpholinium ethosulfate micelles against Staphylococcus species. Nanomedicine, 11, 657-671.
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• Pan, T.L., Wang, P.W., Hung, C.F., Aljuffali, I.A., Dai, Y.S., Fang, J.Y.* (2016) The impact of retinol loading and surface charge on the hepatic delivery of lipid nanoparticles. Colloids Surf. B, 141, 584-594.
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• Aljuffali, I.A., Lin, Y.K., Fang, J.Y.* (2016) Noninvasive approach for enhancing small interfering RNA delivery percutaneously. Expert Opin. Drug Deliv., 13, 265-280.
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• Chuang, S.Y., Lin, C.F., Aljuffali, I.A., Fang, J.Y.* (2016) Specific targeting of engineered nanoparticles to activated macrophages. Curr. Nanosci., 12, 63-69.
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• Fang, Y.P., Yang, S.H., Lee, C.H., Aljuffali, I.A., Kao, H.C., Fang, J.Y.* (2016) What is the discrepancy between drug permeation into/across intact and diseased skins? Atopic dermatitis as a model. Int. J. Pharm., 497, 277-286.

• Fang, J.Y., Lin, Y.K., Wang, S.W., Li, Y.C., Lee, R.S. (2015) Synthesis and characterization of dual-stimuli-responsive micelles based on poly(N-isopropylacrylamide) and polycarbonate with photocleavable moieties. React. Funct. Polym., 95, 46-54.
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• Yang, S.C., Hung, C.F., Aljuffali, I.A., Fang, J.Y.* (2015) The roles of the virulence factor IpaB in Shigella spp. in the escape from immune cells and invasion of epithelial cells. Microbiol. Res., 181, 43-51.
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• Aljuffali, I.A., Huang, C.H., Fang, J.Y.* (2015) Nanomedical strategies for targeting skin microbiomes. Curr. Drug Metab., 16, 255-271.
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• Fang, J.Y., Wang, S.W., Li, Y.C., Lee, R.S. (2015) Bio-recognizable and photo-cleavable block copolymers based on sugar and poly(4-substituted-ε-caprolactone) bearing a photo-cleavable junction. J. Polym. Res., 22, 155.
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• Fang, C.L., Wen, C.J., Aljuffali, I.A., Sung, C.T., Huang, C.L., Fang, J.Y.* (2015) Passive targeting of phosphatiosomes increases rolipram delivery to the lungs for treatment of acute lung injury: an animal study. J. Control. Release, 213, 69-78.
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• Hung, C.F., Chen, W.Y., Hsu, C.Y., Aljuffali, I.A., Shih, H.C., Fang, J.Y.* (2015) Cutaneous penetration of soft nanoparticles via photodamaged skin: lipid-based and polymer-based nanocarriers for drug delivery. Eur. J. Pharm. Biopharm., 94, 94-105.
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• Aljuffali, I.A., Pan, T.L., Sung, C.T., Chang, S.H., Fang, J.Y.* (2015) Anti-PDGF receptor β antibody-conjugated squarticles loaded with minoxidil for alopecia treatment by targeting hair follicles and dermal papilla cells. Nanomed.-Nanotechnol. Biol. Med., 11, 1321-1330.
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• Lee, R.S., Lin, C.H., Aljuffali, I.A., Hu, K.Y., Fang, J.Y.* (2015) Passive targeting of thermosensitive diblock copolymer micelles to the lungs: synthesis and characterization of poly(N-isopropylacrylamide)-block-poly(ε-caprolactone). J. Nanobiotechnol., 13, 42.
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• Aljuffali, I.A., Hsu, C.Y., Lin, Y.K., Fang, J.Y.* (2015) Cutaneous delivery of natural antioxidants: the enhancement approaches. Curr. Pharm. Design, 21, 2745-2757.
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• Lee, W.R., Shen, S.C., Sun, C.K., Aljuffali, I.A., Suen, S.Y., Lin, Y.K., Wang, J.J., Fang, J.Y.* (2015) Fractional thermolysis by bipolar radiofrequency facilitates cutaneous delivery of peptide and siRNA with minor loss of barrier function. Pharm. Res., 32, 1704-1713.
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• Pan, T.L., Wang, P.W., Aljuffali, I.A., Huang, C.T., Lee, C.W., Fang, J.Y.* (2015) The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption. J. Dermatol. Sci., 78, 51-60.
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• Chen, C.H., Chang, C.C., Shih, T.H., Aljuffali, I.A., Yeh, T.S., Fang, J.Y.* (2015) Self-nanoemulsifying drug delivery systems ameliorate the oral delivery of silymarin in rats with Roux-en-Y gastric bypass surgery. Int. J. Nanomed., 10, 2403-2416.
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• Hwang, T.L., Hsu, C.Y., Aljuffali, I.A., Chen, C.H., Chang, Y.T., Fang, J.Y.* (2015) Cationic liposomes evoke inflammatory responses and neutrophil extracellular traps (NETs) toward human neutrophils. Colloids Surf. B, 128, 119-126.
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• Hwang, T.L., Aljuffali, I.A., Lin, C.F., Chang, Y.T., Fang, J.Y.* (2015) Cationic additives in nanosystems interact with human neutrophils to activate cytotoxicity and inflammatory response: lipid nanoparticles versus polymeric nanoparticles. Int. J. Nanomed., 10, 371-385.

• Fang, J.Y., Wang, P.W., Huang, C.H., Hung, Y.Y., Pan, T.L. (2014) Evaluation of the hepatotoxic risk caused by lead acetate via skin exposure using a proteome approach. Proteomics, 14, 2588-2599.
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• Lin, C.F., Wen, C.J., Aljuffali, I.A., Huang, C.L., Fang, J.Y.* (2014) Quantiosomes as a multimodal nanocarrier for integrating bioimaging and anticancer drug delivery. Pharm. Res., 31, 2664-2676.
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• Hsieh, P.W., Aljuffali, I.A., Fang, C.L., Chang, S.H., Fang, J.Y.* (2014) Hydroquinone-salicylic acid conjugates as novel anti-melasma actives show superior skin targeting compared to the parent drugs. J. Dermatol. Sci., 76, 120-131.
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• Hung, C.F., Chen, W.Y., Aljuffali, I.A., Shih, H.C., Fang, J.Y.* (2014) The risk of hydroquinone and sunscreen over-absorption via photodamaged skin is not greater in senescent skin as compared to young skin: nude mouse as an animal model. Int. J. Pharm., 471, 135-145.
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• Yang, S.C., Lin, C.H., Sung, C.T., Fang, J.Y.* (2014) Antibacterial activities of bacteriocins: application in foods and pharmaceuticals. Front. Microbiol., 5, article 241.
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• Lee, W.R., Shen, S.C., Chen, W.Y., Aljuffali, I.A., Suen, S.Y., Fang, J.Y.* (2014) Noninvasive delivery of siRNA and plasmid DNA into skin by fractional ablation: erbium:YAG laser versus CO₂ laser. Eur. J. Pharm. Biopharm., 86, 315-323.
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• Hsieh, P.W., Wen, C.J., Yu, H.P., Aljuffali, I.A., Huang, Y.H., Fang, J.Y.* (2014) Nanostructured lipid carriers containing a high percentage of a Pluronic copolymer increase the biodistribution of novel PDE4 inhibitors for the treatment of traumatic hemorrhage. J. Biomed. Nanotechnol., 10, 1520-1535.
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• Lin, C.H., Aljuffali, I.A., Fang, J.Y.* (2014) Lasers as an approach for promoting drug delivery via skin. Expert Opin. Drug Deliv., 11, 599-614.
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• Pan, T.L., Wang, P.W., Aljuffali, I.A., Leu, Y.L., Hung, Y.Y., Fang, J.Y.* (2014) Coumarin derivatives, but not coumarin itself, cause skin irritation via topical delivery. Toxicol. Lett., 226, 173-181.
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• Lee, W.R., Shen, S.C., Aljuffali, I.A., Li, Y.C., Fang, J.Y.* (2014) Impact of different vehicles for laser-assisted drug permeation via skin: full-surface versus fractional ablation. Pharm. Res., 31, 382-393.
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• Pan, T.L., Wang, P.W., Aljuffali, I.A., Hung, Y.Y., Lin, C.F., Fang, J.Y.* (2014) Dermal toxicity elicited by phthalates: evaluation of skin absorption, immunohistology, and functional proteomics. Food Chem. Toxicol., 65, 105-114.
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• Aljuffali, I.A., Sung, C.T., Shen, F.M., Huang, C.T., Fang, J.Y.* (2014) Squarticles as a lipid nanocarrier for delivering diphencyprone and minoxidil to hair follicles and human dermal papilla cells. AAPS J., 16, 140-150.
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• Hwang, T.L., Sung, C.T., Aljuffali, I.A., Chang, Y.T., Fang, J.Y.* (2014) Cationic surfactants in the form of nanoparticles and micelles elicit different human neutrophil responses: a toxicological study. Colloids Surf. B, 114, 334-341.